Sandbox reserved 915: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Dominique Stephens, Erica Yothment

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 ==Ligand Binding Site==
 [[Image:Overall_ligand.png|left|200px|thumb|Ligand within the Overall Structure of MGL]]
-The <scene name='58/580298/Ligand/1'>Ligand binding pocket</scene>of MGL has a large hydrophobic region with a polar bottom (Bertrand et al. 2010).  The entrance of the binding pocket for MGL contains a lid, which is very flexible (Bertrand et al. 2010).  The binding pocket or tunnel within MGL matches with the overall structure of 2-AG, with 2-AG's polar head being cleaved by the catalytic triad (Bertrand et al. 2010). Bertrand found that in MGL the binding pocket is not adjusted to the ligand's shape.  However, the main movements of MGL associated with ligand binding involved the lid region (Bertrand et al. 2010)
+The <scene name='58/580298/Ligand/1'>ligand binding pocket</scene> of MGL has a large hydrophobic region with a polar bottom (Bertrand et al. 2010).  The entrance of the binding pocket for MGL contains a lid, which is very flexible (Bertrand et al. 2010).  The binding pocket or tunnel within MGL matches with the overall structure of 2-AG, with 2-AG's polar head being cleaved by the catalytic triad (Bertrand et al. 2010). Bertrand found that in MGL the binding pocket is not adjusted to the ligand's shape.  However, the main movements of MGL associated with ligand binding involved the lid region (Bertrand et al. 2010)
 ==Overall Reaction==
 [[Image:Reaction.PNG|350px|thumb|Overall reaction representing the hydrolysis of 2-AG by MGL]]