Sandbox Reserved 919: Difference between revisions
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[[Image:MGLProt.jpg|300 px|left|thumb|Monomer of MGL created in PYMOL (PDB:3PE6)]] | [[Image:MGLProt.jpg|300 px|left|thumb|Monomer of MGL created in PYMOL (PDB:3PE6)]] | ||
==Introduction== | ==Introduction== | ||
'''Monoglyceride Lipase''' ('''MGL''', '''MAGL''', '''MGLL''') is a 33 kDa [http://en.wikipedia.org/wiki/Protein protein] found mostly in the cell membrane. It is a member of the [http://en.wikipedia.org/wiki/Serine_hydrolase serine hydrolase] superfamily and is also classified as part of the [http://en.wikipedia.org/wiki/Alpha/beta_hydrolase_fold α/β hydrolase fold] family. MGL plays a key role in the hydrolysis of 2-arachidonoylglycerol (2-AG), an endocannabinoid that exists in neurons of the central nervous system, into arachidonic acid and glycerol. Due to the vast medical and therapeutic utility of 2-AG, the inhibition of MGL is a high interest target in pharmaceutical research. | '''Monoglyceride Lipase''' ('''MGL''', '''MAGL''', '''MGLL''') is a 33 kDa [http://en.wikipedia.org/wiki/Protein protein] found mostly in the cell membrane. It is a member of the [http://en.wikipedia.org/wiki/Serine_hydrolase serine hydrolase] superfamily and is also classified as part of the [http://en.wikipedia.org/wiki/Alpha/beta_hydrolase_fold α/β hydrolase fold] family. MGL plays a key role in the hydrolysis of 2-arachidonoylglycerol (2-AG), an endocannabinoid that exists in neurons of the central nervous system, into arachidonic acid and glycerol. Due to the vast medical and therapeutic utility of 2-AG, the inhibition of MGL is a high interest target in pharmaceutical research. <ref> PMID:19962385 </ref> | ||