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Mitogen-activated protein kinase: Difference between revisions

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[[Mitogen-activated protein kinase]] (MAPK) also known as Extracellular Signal-Regulated Kinase (ERK) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more.  MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation.  MAPK1 and MAPK3 are activated in response to growth factors. For MAPK2 representations see [[Michael Roberts/BIOL115/ERK2]].  MAPK6 is activated by phorbol esters.  MAPK7 is activated by stress stimuli.  MAPK8, MAPK9, MAPK10 (called also c-Jun N-terminal kinase 3 or JNK3), MAPK11, MAPK12, MAPK13, MAPK14 are stress-activated. MAPK11, MAPK12, MAPK13, MAPK14 belong to the class called p38 MAPK.  images on the left and right  correspond to one representative MAPK structure, ''i.e.'' the rat MAPK1 ([[1erk]]).
[[Mitogen-activated protein kinase]] (MAPK) also known as Extracellular Signal-Regulated Kinase (ERK) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more.  MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation.  MAPK1 and MAPK3 are activated in response to growth factors. For MAPK2 representations see [[Michael Roberts/BIOL115/ERK2]].  MAPK6 is activated by phorbol esters.  MAPK7 is activated by stress stimuli.  MAPK8, MAPK9, MAPK10 (called also c-Jun N-terminal kinase 3 or JNK3), MAPK11, MAPK12, MAPK13, MAPK14 are stress-activated. MAPK11 (also called p38-β MAPK), MAPK12 (also called p38-γ MAPK), MAPK13 (also called p38-δ MAPK), MAPK14(also called p38-α MAPK) belong to the class called p38 MAPK.  images on the left and right  correspond to one representative MAPK structure, ''i.e.'' the rat MAPK1 ([[1erk]]).


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===MAPK1===  
===MAPK1===
[[3i5z]], [[3i60]], [[2e14]], [[2ojg]], [[2oji]], [[2ojj]], [[1wzy]], [[1tvo]] – hMAPK1+inhibitor - human<br />
[[4g6n]], [[4g6o]], [[4gsb]] – hMAPK1 - human<br />
[[2z7l]], [[3c9w]], [[3qyw]], [[3qyz]] - rMAPK1+inhibitor – rat<br />
[[3i5z]], [[3i60]], [[2e14]], [[2ojg]], [[2oji]], [[2ojj]], [[1wzy]], [[1tvo]], [[3sa0]], [[4fux]], [[4fuy]], [[4fv0]], [[4fv1]], [[4fv2]], [[4fv3]], [[4fv4]], [[4fv5]], [[4fv6]], [[4fv7]], [[4fv8]], [[4fv9]] – hMAPK1+inhibitor - human<br />
[[2y9q]] – hMAPK1 + MAP kinase-interacting Ser/Thr protein kinase peptide<br />
[[3tei]] – hMAPK1 (mutant) + ribosomal protein S6 kinase α-1<br />
[[4iz5]], [[4iz7]], [[4iza]] – hMAPK1 (mutant) + astrocytic phosphoprotein <br />
[[4fmq]] – hMAPK1 + MAPK docking peptide<br />
[[4h3q]] – hMAPK1 + MAP2K 2 peptide<br />
[[2z7l]], [[3c9w]], [[3qyw]], [[3qyz]], [[3qyi]] - rMAPK1+inhibitor – rat<br />
[[1erk]] - rMAPK1<br />
[[1erk]] - rMAPK1<br />
[[1gol]], [[3r63]] - rMAPK1 (mutant)<br />
[[1gol]], [[3r63]] - rMAPK1 (mutant)<br />
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[[3o71]] - rMAPK1 + colorectal cancer peptide<br />
[[3o71]] - rMAPK1 + colorectal cancer peptide<br />
[[2fys]] - rMAPK1 + KIM peptide<br />
[[2fys]] - rMAPK1 + KIM peptide<br />
 
[[4gt3]], [[4gva]] – rMAPK1 + nucleotide<br />
[[4i5h]] – rMAPK1 (mutant) + inhibitor<br />
[[3o71]] - rMAPK1 + colorectal cancer peptide<br />
[[3zu7]], [[3zuv]] – rMAPK1 + ankyrin repeat protein<br />
[[2y4i]] – raMAPK1+kinase suppressor of RAS 2 – rabbit<br />
[[2y4i]] – raMAPK1+kinase suppressor of RAS 2 – rabbit<br />
[[3oz6]] - MAPK1 - Cryptosporidium parvum
[[3oz6]] - MAPK1 - ''Cryptosporidium parvum''


===MAPK2===
===MAPK2===
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===MAPK7===
===MAPK7===
 
[[2q8y]] - MAPK7+Virulence protein
[[4ic8]] – hMAPK7<br />
[[4b99]] – hMAPK7+inhibitor<br />
[[4ic7]] – hMAPK7+ MAP2K 5<br />


===MAPK8===
===MAPK8===


[[3o17]], [[2gmx]], [[2g01]] – hMAPK8 (mutant)+JIP1 peptide<br />
[[3o17]], [[2gmx]], [[2g01]], [[3vud]], [[3vug]], [[3vuh]], [[3vui]], [[3vuk]], [[3vul]], [[3vum]] – hMAPK8 (mutant)+JIP1 peptide<br />
[[1ukh]], [[1uki]] - jMAPK8 JNK1+JIP1 peptide<br />
[[1ukh]], [[1uki]] - jMAPK8 JNK1+JIP1 peptide<br />
[[3v3v]] - hMAPK8 JNK1+JIP1 peptide + quercedagetin<br />
[[3o2m]] - hMAPK8 (mutant)+JIP1 peptide+biaryl tetrazole<br />
[[3o2m]] - hMAPK8 (mutant)+JIP1 peptide+biaryl tetrazole<br />
[[2xrw]], [[2xs0]] - hMAPK8 + NFAT peptide<br />
[[2xrw]], [[2xs0]] - hMAPK8 + NFAT peptide<br />
[[3elj]] - hMAPK8+inhibitor<br />
[[3elj]], [[3pze]], [[4awi]], [[4l7f]] - hMAPK8+inhibitor<br />
[[4e73]], [[4g1w]], [[4hys]], [[4hyu]], [[4izy]] – hMAPK8 + JIP1 +inhibitor<br />
[[2no3]], [[2h96]] – hMAPK8 (mutant)+inhibitor<br />
[[2no3]], [[2h96]] – hMAPK8 (mutant)+inhibitor<br />


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===MAPK10===
===MAPK10===


[[3kvx]], [[3fv8]], [[2waj]], [[3fi2]], [[3fi3]], [[3da6]], [[2zdt]], [[2zdu]], [[3cgf]], [[3cgo]], [[2r9s]], [[2o0u]], [[2o2u]], [[2exc]], [[2b1p]], [[1pmn]], [[1pmq]], [[1pmu]], [[1pmv]], [[3oy1]], [[2ok1]], [[3ttj]], [[3tti]], – hMAPK10+inhibitor<br />
[[3kvx]], [[3fv8]], [[2waj]], [[3fi2]], [[3fi3]], [[3da6]], [[2zdt]], [[2zdu]], [[3cgf]], [[3cgo]], [[2r9s]], [[2o0u]], [[2o2u]], [[2exc]], [[2b1p]], [[1pmn]], [[1pmq]], [[1pmu]], [[1pmv]], [[3oy1]], [[2ok1]], [[3ttj]], [[3tti]], [[3rtp]], [[3v6r]], [[3v6s]] – hMAPK10+inhibitor<br />
[[3ptg]], [[4h39]] - hMAPK10 catalytic domain + JIP1 peptide <br />
[[3ptg]], [[4h39]] - hMAPK10 catalytic domain + JIP1 peptide <br />
[[4h36]] – hMAPK10 catalytic domain + ATF2 peptide<br />
[[4h36]] – hMAPK10 catalytic domain + ATF2 peptide<br />
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===MAPK13===
===MAPK13===
[[3coi]] – hMAPK13<br />
 
[[3coi]], [[4exu]] – hMAPK13<br />
[[4eyj]], [[4eym]] - hMAPK13 +inhibitor<br />


===MAPK14===
===MAPK14===


[[3mgy]], [[3mh0]], [[3mh1]], [[3mh2]], [[3mh3]], [[3hvc]], [[3npq]], [[1wbo]], [[1r39]], [[2npq]] – hMAPK14<br />
[[3mgy]], [[3mh0]], [[3mh1]], [[3mh2]], [[3mh3]], [[3hvc]], [[3npq]], [[1wbo]], [[1r39]], [[2npq]], [[1wfc]], [[1cm8]] – hMAPK14<br />
[[3od6]], [[3ody]], [[3odz]], [[3oef]], [[3p4k]], [[2fsl]], [[2fsm]], [[2fso]], [[2fst]], [[1r3c]] – hMAPK14 (mutant)<br />
[[2lgc]] – hMAPK14 – NMR<br />
[[3new]], [[3ocg]], [[3mvl]], [[3mvm]], [[3nnu]], [[3nnv]], [[3nnw]], [[3nnx]], [[3nww]], [[3mpt]], [[3lhj]], [[3huc]], [[3itz]], [[3l8x]], [[3kf7]], [[3fi4]], [[3fkl]], [[3fkn]], [[3fko]], [[3fl4]], [[3fln]], [[3flq]], [[3fls]], [[3flw]], [[3fly]], [[3flz]], [[3fmh]], [[3fmj]], [[3fmk]], [[3fml]], [[3flm]], [[3fln]], [[3fsf]], [[3fsk]], [[3kq7]], [[3iph]], [[3hv4]], [[3hv5]], [[3hv6]], [[3hv7]], [[3k3i]], [[3hec]], [[3heg]], [[3gi3]], [[3hp2]], [[3hp5]], [[3hrb]], [[3ha8]], [[3gfe]], [[3hl7]], [[3hll]], [[3gcu]], [[3fc1]], [[3dt1]], [[3e92]], [[3e93]], [[3d7z]], [[3d83]], [[3ctq]], [[2puu]], [[3bx5]], [[3c5u]], [[2zaz]], [[2zb0]], [[2zb1]], [[2qd9]], [[2ewa]], [[2gfs]], [[2baj]], [[2bak]], [[2bal]], [[2baq]], [[1zyj]], [[1wbn]], [[1wbs]], [[1wbt]], [[1wbv]], [[1wbw]], [[1zz2]], [[1zzl]], [[1yqj]], [[1w7h]], [[1w82]], [[1w83]], [[1w84]], [[1oz1]], [[1ouk]], [[1ouy]], [[1m7q]], [[1kv1]], [[1kv2]], [[1di9]], [[2rg5]], [[2rg6]], [[3bv3]], [[3bv2]], [[3fmm]], [[3fmn]], [[3lfa]], [[3mw1]], [[3pg3]], [[3roc]] - hMAPK14+inhibitor<br />
[[3od6]], [[3ody]], [[3odz]], [[3oef]], [[3p4k]], [[2fsl]], [[2fsm]], [[2fso]], [[2fst]], [[1r3c]], [[4e5a]], [[4geo]] – hMAPK14 (mutant)<br />
[[3o8t]], [[3mpa]], [[3obg]], [[3o8u]], [[3o8p]], [[3obj]], [[3oc1]], [[3hub]], [[3l8s]], [[3hv3]], [[3iw5]], [[3iw6]], [[3iw7]], [[3iw8]], [[3k3j]], [[3gc7]], [[3gcp]], [[3gcq]], [[3gcs]], [[3gcv]], [[3ds6]], [[2i0h]], [[1ove]], [[3lfb]], [[3lfc]], [[3lfd]], [[3lfe]], [[3lff]] - hMAPK14 (mutant)+inhibitor<br />
[[3new]], [[3ocg]], [[3mvl]], [[3mvm]], [[3nnu]], [[3nnv]], [[3nnw]], [[3nnx]], [[3nww]], [[3mpt]], [[3lhj]], [[3huc]], [[3itz]], [[3l8x]], [[3kf7]], [[3fi4]], [[3fkl]], [[3fkn]], [[3fko]], [[3fl4]], [[3fln]], [[3flq]], [[3fls]], [[3flw]], [[3fly]], [[3flz]], [[3fmh]], [[3fmj]], [[3fmk]], [[3fml]], [[3flm]], [[3fln]], [[3fsf]], [[3fsk]], [[3kq7]], [[3iph]], [[3hv4]], [[3hv5]], [[3hv6]], [[3hv7]], [[3k3i]], [[3hec]], [[3heg]], [[3gi3]], [[3hp2]], [[3hp5]], [[3hrb]], [[3ha8]], [[3gfe]], [[3hl7]], [[3hll]], [[3gcu]], [[3fc1]], [[3dt1]], [[3e92]], [[3e93]], [[3d7z]], [[3d83]], [[3ctq]], [[2puu]], [[3bx5]], [[3c5u]], [[2zaz]], [[2zb0]], [[2zb1]], [[2qd9]], [[2ewa]], [[2gfs]], [[2baj]], [[2bak]], [[2bal]], [[2baq]], [[1zyj]], [[1wbn]], [[1wbs]], [[1wbt]], [[1wbv]], [[1wbw]], [[1zz2]], [[1zzl]], [[1yqj]], [[1w7h]], [[1w82]], [[1w83]], [[1w84]], [[1oz1]], [[1ouk]], [[1ouy]], [[1m7q]], [[1kv1]], [[1kv2]], [[1di9]], [[2rg5]], [[2rg6]], [[3bv3]], [[3bv2]], [[3fmm]], [[3fmn]], [[3lfa]], [[3mw1]], [[3pg3]], [[3roc]] ,[[2yis]], [[2yiw]], [[2yix]], [[3qud]], [[3que]], [[3rin]], [[3s3i]], [[3s4q]], [[3u8w]], [[3uvp]], [[3uvq]], [[3uvr]], [[3zs5]], [[3zsg]], [[3zsh]], [[3zsi]], [[3zya]], [[4a9y]], [[4aa0]], [[4aa4]], [[4aa5]], [[4aac]], [[4dli]], [[4dlj]], [[4e5b]], [[4eh2]], [[4eh3]], [[4eh4]], [[4eh5]], [[4eh6]], [[4eh7]], [[4eh8]], [[4eh9]], [[4ehv]], [[4ewq]], [[4f9w]], [[4f9y]], [[4fa2]], [[4kin]], [[4kip]], [[4kiq]], [[4l8m]] - hMAPK14+inhibitor<br />
[[4e6a]], [[4e6c]], [[4e8a]] - hMAPK14+ lipid<br />
[[3o8t]], [[3mpa]], [[3obg]], [[3o8u]], [[3o8p]], [[3obj]], [[3oc1]], [[3hub]], [[3l8s]], [[3hv3]], [[3iw5]], [[3iw6]], [[3iw7]], [[3iw8]], [[3k3j]], [[3gc7]], [[3gcp]], [[3gcq]], [[3gcs]], [[3gcv]], [[3ds6]], [[2i0h]], [[1ove]], [[3lfb]], [[3lfc]], [[3lfd]], [[3lfe]], [[3lff]], [[1bl6]], [[1bl7]], [[1bmk]], [[1a9u]], [[1ian]] - hMAPK14 (mutant)+inhibitor<br />
[[2y8o]] – hMAPK14 (mutant) + dual specificity MAP2K peptide<br />
[[4ka3]], [[4loo]], [[4lop]], [[4loq]] – hMAPK14 + docking peptide<br />
[[3tg1]] – hMAPK14 + MAPK phosphatase 5<br />
[[2gtn]], [[2gtm]], [[3p5k]], [[3p78]], [[3p79]], [[3p7a]], [[3p7b]], [[3p7c]] - mMAPK14+inhibitor<br />
[[2gtn]], [[2gtm]], [[3p5k]], [[3p78]], [[3p79]], [[3p7a]], [[3p7b]], [[3p7c]] - mMAPK14+inhibitor<br />
[[2ghm]], [[2ghl]], [[1ywr]] - mMAPK14 (mutant)+inhibitor<br />
[[2ghm]], [[2ghl]], [[1ywr]] - mMAPK14 (mutant)+inhibitor<br />
[[3py3]] - mMAPK14 phosphorylated<br />
[[3py3]] - mMAPK14 phosphorylated<br />
[[1yw2]] - mMAPK14 (mutant)<br />
[[1yw2]], [[1p38]] - mMAPK14 (mutant)<br />
[[1lew]] - mMAPK14+MEF2A<br />
[[1lew]] - mMAPK14+MEF2A<br />
[[1lez]] - mMAPK14+MKK3B<br />
[[1lez]] - mMAPK14+MKK3B<br />
===MAPK p38===
[[1wfc]] - hMAPK p38<br />
[[1bl6]], [[1bl7]], [[1bmk]], [[1a9u]], [[1ian]] – hMAPK p38 (mutant)+inhibitor<br />
[[1p38]] - mMAPK p38 (mutant) - mouse<br />


===MAPK FUSS===
===MAPK FUSS===
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[[2b9j]] - yMAPK FUSS (mutant)+FAR1 peptide<br />
[[2b9j]] - yMAPK FUSS (mutant)+FAR1 peptide<br />


[[3rp9]] – MAPK – ''Toxoplasma gondii''
[[3rp9]] – MAPK – ''Toxoplasma gondii''<br />
[[3uib]] – MAPK + inhibitor – ''Leishmania major''<br />


[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman
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