4o4j: Difference between revisions
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{{STRUCTURE_4o4j| PDB=4o4j | SCENE= }} | |||
===Tubulin-Peloruside A complex=== | |||
{{ABSTRACT_PUBMED_24470331}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). | |||
==About this Structure== | |||
[[4o4j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4J OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024470331</ref><references group="xtra"/><references/> | |||
[[Category: Bos taurus]] | |||
[[Category: Altmann, K H.]] | |||
[[Category: Bargsten, K.]] | |||
[[Category: Diaz, J F.]] | |||
[[Category: Marsh, M.]] | |||
[[Category: Miller, J H.]] | |||
[[Category: Northcote, P T.]] | |||
[[Category: Prota, A E.]] | |||
[[Category: Steinmetz, M O.]] | |||
[[Category: Alpha-tubulin]] | |||
[[Category: Beta-tubulin]] | |||
[[Category: Cell cycle]] | |||
[[Category: Cell cycle-inhibitor complex]] | |||
[[Category: Cytoskeleton]] | |||
[[Category: Gtpase]] | |||
[[Category: Ligase]] | |||
[[Category: Microtubule]] | |||
[[Category: Peloruside some]] | |||
[[Category: Stathmin]] | |||
[[Category: Tubulin fold]] | |||
Revision as of 12:23, 26 March 2014
Tubulin-Peloruside A complexTubulin-Peloruside A complex
Template:ABSTRACT PUBMED 24470331
FunctionFunction
[TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [STMN4_RAT] Exhibits microtubule-destabilizing activity.[1] [2] [3] [TBB2B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
About this StructureAbout this Structure
4o4j is a 6 chain structure with sequence from [1] and Bos taurus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Prota AE, Bargsten K, Northcote PT, Marsh M, Altmann KH, Miller JH, Diaz JF, Steinmetz MO. Structural basis of microtubule stabilization by laulimalide and peloruside a. Angew Chem Int Ed Engl. 2014 Feb 3;53(6):1621-5. doi: 10.1002/anie.201307749., Epub 2014 Jan 27. PMID:24470331 doi:http://dx.doi.org/10.1002/anie.201307749
- ↑ Nakao C, Itoh TJ, Hotani H, Mori N. Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neuron-specific member of the SCG10 family, by its N-terminal domain. J Biol Chem. 2004 May 28;279(22):23014-21. Epub 2004 Mar 22. PMID:15039434 doi:http://dx.doi.org/10.1074/jbc.M313693200
- ↑ Gavet O, El Messari S, Ozon S, Sobel A. Regulation and subcellular localization of the microtubule-destabilizing stathmin family phosphoproteins in cortical neurons. J Neurosci Res. 2002 Jun 1;68(5):535-50. PMID:12111843 doi:http://dx.doi.org/10.1002/jnr.10234
- ↑ Ravelli RB, Gigant B, Curmi PA, Jourdain I, Lachkar S, Sobel A, Knossow M. Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain. Nature. 2004 Mar 11;428(6979):198-202. PMID:15014504 doi:http://dx.doi.org/10.1038/nature02393