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 ==Overview==
-Beef liver and human erythrocyte catalases (EC 1.11.1.6) bind NADP, tenaciously [Kirkman, H. N. &amp; Gaetani, G. F. (1984) Proc. Natl. Acad. Sci., USA 81, 4343-4348]. The position of NADP on beef liver catalase, corresponds to the carboxyl-terminal polypeptide hinge in Penicillium, vitale fungal catalase, which connects the common catalase structure to, the additional flavodoxin-like domain. In contrast to nearly all other, known structures of protein-bound NADP, NAD, and FAD, the NADP molecule of, beef liver catalase is folded into a right-handed helix and bound, in, part, in the vicinity of the carboxyl end of two alpha-helices. A water, molecule (W7) occupies a pseudosubstrate site close to the C4 position of, the nicotinamide and is hydrogen bonded to His-304. Although the NADP and, heme groups approach each other to within 13.7 A, there is no direct, interaction. The function of the NADP remains a mystery.
+Beef liver and human erythrocyte catalases (EC 1.11.1.6) bind NADP tenaciously [Kirkman, H. N. &amp; Gaetani, G. F. (1984) Proc. Natl. Acad. Sci. USA 81, 4343-4348]. The position of NADP on beef liver catalase corresponds to the carboxyl-terminal polypeptide hinge in Penicillium vitale fungal catalase, which connects the common catalase structure to the additional flavodoxin-like domain. In contrast to nearly all other known structures of protein-bound NADP, NAD, and FAD, the NADP molecule of beef liver catalase is folded into a right-handed helix and bound, in part, in the vicinity of the carboxyl end of two alpha-helices. A water molecule (W7) occupies a pseudosubstrate site close to the C4 position of the nicotinamide and is hydrogen bonded to His-304. Although the NADP and heme groups approach each other to within 13.7 A, there is no direct interaction. The function of the NADP remains a mystery.
 ==About this Structure==
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 [[Category: Catalase]]
 [[Category: Single protein]]
-[[Category: /III, T.J.Reid.]]
+[[Category: /III, T J.Reid.]]
 [[Category: Fita, I.]]
-[[Category: Murthy, M.R.N.]]
+[[Category: Murthy, M R.N.]]
-[[Category: Rossmann, M.G.]]
+[[Category: Rossmann, M G.]]
 [[Category: Sicignano, A.]]
 [[Category: Tanaka, N.]]
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 [[Category: oxidoreductase (h2o2 acceptor)]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 21:51:06 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:16:57 2008''