6pfk: Difference between revisions

[[Image:6pfk.gif|left|200px]]<br />

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Comparison between the crystal structures of low- and high-affinity forms, of phosphofructokinase shows a close coupling between the change of, quaternary structure and local changes triggered by binding of the, allosteric effectors. These concerted changes link all the substrate and, effector sites in the tetramer, and explain the change of affinity for the, cooperative substrate.

6PFK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus] with PGA as [http://en.wikipedia.org/wiki/ligand ligand]. This structure superseeds the now removed PDB entry 5PFK. The following page contains interesting information on the relation of 6PFK with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb50_1.html The Glycolytic Enzymes]]. Active as [http://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=6PFK OCA].  

[[Category: Evans, P.R.]]

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