4nn5: Difference between revisions

Revision as of 12:40, 19 March 2014

Cytokine receptor complex - Crystal form 1ACytokine receptor complex - Crystal form 1A

FunctionFunction

[TSLP_MOUSE] Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity). [CRLF2_MOUSE] Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. [IL7RA_MOUSE] Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

About this StructureAbout this Structure

4nn5 is a 3 chain structure. Full crystallographic information is available from OCA.

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4nn5|  PDB=4nn5  |  SCENE=  }}
+===Cytokine receptor complex - Crystal form 1A===
-The entry 4nn5 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/TSLP_MOUSE TSLP_MOUSE]] Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity). [[http://www.uniprot.org/uniprot/CRLF2_MOUSE CRLF2_MOUSE]] Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. [[http://www.uniprot.org/uniprot/IL7RA_MOUSE IL7RA_MOUSE]] Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
-Authors: Verstraete, K., van Schie, L., Savvides, S.N.
+==About this Structure==
+[[4nn5]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NN5 OCA].
-Description: Cytokine receptor complex -Crystal form 1A
+[[Category: Savvides, S N.]]
+[[Category: Schie, L van.]]
+[[Category: Verstraete, K.]]
+[[Category: Cell surface]]
+[[Category: Chr domain]]
+[[Category: Cytokine-cytokine receptor complex]]
+[[Category: Four helical bundle fold]]
+[[Category: Tslp cytokine signaling]]
+[[Category: Tslpr and il-7ralpha receptor]]