4jyt: Difference between revisions
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{{STRUCTURE_4jyt| PDB=4jyt | SCENE= }} | |||
===Crystal Structure of Matriptase in complex with Inhibitor=== | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[http://omim.org/entry/610765 610765]]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. | |||
==About this Structure== | |||
[[4jyt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYT OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Matriptase]] | |||
[[Category: Ashok, K N.]] | |||
[[Category: Chakshusmathi, G.]] | |||
[[Category: Ramesh, K S.]] | |||
[[Category: Ravi, B C.]] | |||
[[Category: Subramanya, H S.]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Matriptase]] |