4o7c: Difference between revisions
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{{STRUCTURE_4o7c| PDB=4o7c | SCENE= }} | |||
===Crystal structure of the first bromodomain of human BRD4 in complex with SB-614067-R=== | |||
{{ABSTRACT_PUBMED_24568369}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
==About this Structure== | |||
[[4o7c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O7C OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024568369</ref><references group="xtra"/><references/> | |||
[[Category: Ember, S W.]] | |||
[[Category: Schonbrunn, E.]] | |||
[[Category: Watts, C.]] | |||
[[Category: Zhu, J Y.]] | |||
[[Category: Bromodomain]] | |||
[[Category: Cap]] | |||
[[Category: Cell cycle]] | |||
[[Category: Hunk1]] | |||
[[Category: Inhibitor]] | |||
[[Category: Mcap]] | |||
[[Category: Mitotic chromosome associated protein]] | |||
[[Category: Protein binding-inhibitor complex]] | |||
[[Category: Transcription-inhibitor complex]] |