4o7e: Difference between revisions
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{{STRUCTURE_4o7e| PDB=4o7e | SCENE= }} | |||
===Crystal structure of the first bromodomain of human BRD4 in complex with SB-610251-B=== | |||
{{ABSTRACT_PUBMED_24568369}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
==About this Structure== | |||
[[4o7e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O7E OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024568369</ref><references group="xtra"/><references/> | |||
[[Category: Ember, S W.]] | |||
[[Category: Schonbrunn, E.]] | |||
[[Category: Watts, C.]] | |||
[[Category: Zhu, J Y.]] | |||
[[Category: Bromodomain]] | |||
[[Category: Cap]] | |||
[[Category: Cell cycle]] | |||
[[Category: Hunk1]] | |||
[[Category: Inhibitor]] | |||
[[Category: Mcap]] | |||
[[Category: Mitotic chromosome associated protein]] | |||
[[Category: Protein binding-inhibitor complex]] | |||
[[Category: Transcription-inhibitor complex]] | |||
Revision as of 11:52, 19 March 2014
Crystal structure of the first bromodomain of human BRD4 in complex with SB-610251-BCrystal structure of the first bromodomain of human BRD4 in complex with SB-610251-B
Template:ABSTRACT PUBMED 24568369
DiseaseDisease
[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]
FunctionFunction
[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
About this StructureAbout this Structure
4o7e is a 2 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Ember SW, Zhu JY, Olesen SH, Martin MP, Becker A, Berndt N, Georg GI, Schonbrunn E. Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors. ACS Chem Biol. 2014 Mar 13. PMID:24568369 doi:http://dx.doi.org/10.1021/cb500072z
- ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
- ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0