4n8m: Difference between revisions
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{{STRUCTURE_4n8m| PDB=4n8m | SCENE= }} | |||
===Structural polymorphism in the N-terminal oligomerization domain of NPM1=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NPM_MOUSE NPM_MOUSE]] Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules (By similarity). Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication (By similarity). Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation (By similarity). | |||
==About this Structure== | |||
[[4n8m]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8M OCA]. | |||
[[Category: Babu, M M.]] | |||
[[Category: Buljan, M.]] | |||
[[Category: Kriwacki, R W.]] | |||
[[Category: Mitrea, D.]] | |||
[[Category: Nourse, A.]] | |||
[[Category: Park, C.]] | |||
[[Category: Pytel, N.]] | |||
[[Category: Royappa, G.]] | |||
[[Category: Satumba, J.]] | |||
[[Category: White, S W.]] | |||
[[Category: Yun, M.]] | |||
[[Category: Chaperone]] | |||
[[Category: Histone chaperone]] | |||
[[Category: Nucleolar protein]] | |||
[[Category: Pentamer]] | |||
[[Category: Phosphoprotein]] | |||
[[Category: Regulated unfolding]] | |||
[[Category: Ribosome biogenesis]] | |||
[[Category: Structural polymorphism]] | |||
Revision as of 17:01, 12 March 2014
Structural polymorphism in the N-terminal oligomerization domain of NPM1Structural polymorphism in the N-terminal oligomerization domain of NPM1
FunctionFunction
[NPM_MOUSE] Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules (By similarity). Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication (By similarity). Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation (By similarity).
About this StructureAbout this Structure
4n8m is a 5 chain structure. Full crystallographic information is available from OCA.