2brr: Difference between revisions
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Revision as of 17:41, 30 October 2007
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COMPLEX OF THE NEISSERIAL PORA P1.4 EPITOPE PEPTIDE AND TWO FAB-FRAGMENTS (ANTIBODY MN20B9.34)
OverviewOverview
In various western countries, subtype P1.4 of Neisseria meningitidis, serogroup B causes the greatest incidence of meningococcal disease. To, investigate the molecular recognition of this subtype, we crystallised a, peptide (P1HVVVNNKVATH(P11)), corresponding to the subtype P1.4 epitope, sequence of outer membrane protein PorA, in complex with a Fab fragment of, the bactericidal antibody MN20B9.34 directed against this epitope., Structure determination at 1.95 A resolution revealed a unique complex of, one P1.4 antigen peptide bound to two identical Fab fragments. One Fab, recognises the putative epitope residues in a 2:2 type I beta-turn at, residues P5NNKV(P8), whereas the other Fab binds the C-terminal residues, of the peptide that we consider a crystallisation artefact. Interestingly, ... [(full description)]
About this StructureAbout this Structure
2BRR is a [Protein complex] structure of sequences from [Mus musculus] with SO4, NH2 and ACY as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of an Anti-meningococcal subtype P1.4 PorA antibody provides basis for peptide-vaccine design., Oomen CJ, Hoogerhout P, Kuipers B, Vidarsson G, van Alphen L, Gros P, J Mol Biol. 2005 Sep 2;351(5):1070-80. PMID:16038932
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