4i1b: Difference between revisions
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==Overview== | ==Overview== | ||
The molecular structure of interleukin-1 beta, a hormone-like cytokine | The molecular structure of interleukin-1 beta, a hormone-like cytokine with roles in several disease processes, has been determined at 2.0 A resolution and refined to a crystallographic R-factor of 0.19. The framework of this molecule consists of 12 antiparallel beta-strands exhibiting pseudo-3-fold symmetry. Six of the strands make up a beta-barrel with polar residues concentrated at either end. Analysis of the three-dimensional structure, together with results from site-directed mutagenesis and biochemical and immunological studies, suggest that the core of the beta-barrel plays an important functional role. A large patch of charged residues on one end of the barrel is proposed as the binding surface with which IL-1 interacts with its receptor. | ||
==Disease== | ==Disease== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Gilliland, G | [[Category: Gilliland, G L.]] | ||
[[Category: Hirai, Y.]] | [[Category: Hirai, Y.]] | ||
[[Category: Masui, Y.]] | [[Category: Masui, Y.]] | ||
[[Category: Poulos, T | [[Category: Poulos, T L.]] | ||
[[Category: Raag, R.]] | [[Category: Raag, R.]] | ||
[[Category: Svensson, L | [[Category: Svensson, L A.]] | ||
[[Category: Veerapandian, B.]] | [[Category: Veerapandian, B.]] | ||
[[Category: cytokine]] | [[Category: cytokine]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:13:35 2008'' | ||