4jz1: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4jz1| PDB=4jz1 | SCENE= }} | |||
===Crystal Structure of Matriptase in complex with Inhibitor=== | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[http://omim.org/entry/610765 610765]]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. | |||
==About this Structure== | |||
[[4jz1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JZ1 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Matriptase]] | |||
[[Category: Ashok, K N.]] | |||
[[Category: Chakshusmathi, G.]] | |||
[[Category: Ramesh, K S.]] | |||
[[Category: Ravi, B C.]] | |||
[[Category: Subramanya, H S.]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Matriptase]] | |||
Revision as of 21:21, 3 March 2014
Crystal Structure of Matriptase in complex with InhibitorCrystal Structure of Matriptase in complex with Inhibitor
DiseaseDisease
[ST14_HUMAN] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.[1]
FunctionFunction
[ST14_HUMAN] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
About this StructureAbout this Structure
4jz1 is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Basel-Vanagaite L, Attia R, Ishida-Yamamoto A, Rainshtein L, Ben Amitai D, Lurie R, Pasmanik-Chor M, Indelman M, Zvulunov A, Saban S, Magal N, Sprecher E, Shohat M. Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase. Am J Hum Genet. 2007 Mar;80(3):467-77. Epub 2007 Jan 23. PMID:17273967 doi:S0002-9297(07)60095-0