407d: Difference between revisions

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OCA

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 ==Overview==
-Polyamide dimers containing three types of aromatic rings-pyrrole, imidazole, and hydroxypyrrole-afford a small-molecule recognition code, that discriminates among all four Watson-Crick base pairs in the minor, groove. The crystal structure of a specific polyamide dimer-DNA complex, establishes the structural basis for distinguishing T.A from A.T base, pairs. Specificity for the T.A base pair is achieved by means of distinct, hydrogen bonds between pairs of substituted pyrroles on the ligand and the, O2 of thymine and N3 of adenine. In addition, shape-selective recognition, of an asymmetric cleft between the thymine-O2 and the adenine-C2 was, observed. Although hitherto similarities among the base pairs in the minor, groove have been emphasized, the structure illustrates differences that, allow specific minor groove recognition.
+Polyamide dimers containing three types of aromatic rings-pyrrole, imidazole, and hydroxypyrrole-afford a small-molecule recognition code that discriminates among all four Watson-Crick base pairs in the minor groove. The crystal structure of a specific polyamide dimer-DNA complex establishes the structural basis for distinguishing T.A from A.T base pairs. Specificity for the T.A base pair is achieved by means of distinct hydrogen bonds between pairs of substituted pyrroles on the ligand and the O2 of thymine and N3 of adenine. In addition, shape-selective recognition of an asymmetric cleft between the thymine-O2 and the adenine-C2 was observed. Although hitherto similarities among the base pairs in the minor groove have been emphasized, the structure illustrates differences that allow specific minor groove recognition.
 ==About this Structure==
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 [[Category: drugs in the dna minor groove]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 21:42:18 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:11:57 2008''