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{{STRUCTURE_4bwl| PDB=4bwl | SCENE= }} | |||
===Structure of the Y137A mutant of E. coli N-acetylneuraminic acid lyase in complex with pyruvate, N-acetyl-D-mannosamine and N- acetylneuraminic acid=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NANA_ECOLI NANA_ECOLI]] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.[HAMAP-Rule:MF_01237] | |||
==About this Structure== | |||
[[4bwl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWL OCA]. | |||
[[Category: N-acetylneuraminate lyase]] | |||
[[Category: Berry, A.]] | |||
[[Category: Campeotto, I.]] | |||
[[Category: Nelson, A.]] | |||
[[Category: Pearson, A R.]] | |||
[[Category: Phillips, S E.V.]] | |||
[[Category: Directed evolution]] | |||
[[Category: Lyase]] | |||
[[Category: Protein engineering]] | |||
[[Category: Substrate specificity]] | |||
Revision as of 20:43, 19 February 2014
Structure of the Y137A mutant of E. coli N-acetylneuraminic acid lyase in complex with pyruvate, N-acetyl-D-mannosamine and N- acetylneuraminic acidStructure of the Y137A mutant of E. coli N-acetylneuraminic acid lyase in complex with pyruvate, N-acetyl-D-mannosamine and N- acetylneuraminic acid
FunctionFunction
[NANA_ECOLI] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.[HAMAP-Rule:MF_01237]
About this StructureAbout this Structure
4bwl is a 4 chain structure. Full crystallographic information is available from OCA.