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{{STRUCTURE_4lek| PDB=4lek | SCENE= }} | |||
===Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines=== | |||
{{ABSTRACT_PUBMED_24428639}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
==About this Structure== | |||
[[4lek]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEK OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024428639</ref><references group="xtra"/><references/> | |||
[[Category: Dihydrofolate reductase]] | |||
[[Category: Hilgers, M T.]] | |||
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | |||
Revision as of 20:27, 19 February 2014
Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolinesStructure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines
Template:ABSTRACT PUBMED 24428639
FunctionFunction
[DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this StructureAbout this Structure
4lek is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Lam T, Hilgers MT, Cunningham ML, Kwan BP, Nelson KJ, Brown-Driver V, Ong V, Trzoss M, Hough G, Shaw KJ, Finn J. Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines. J Med Chem. 2014 Feb 13;57(3):651-68. doi: 10.1021/jm401204g. Epub 2014 Jan 16. PMID:24428639 doi:http://dx.doi.org/10.1021/jm401204g