CD3: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD2 extracellular domain (grey) complex with antibody light chain (aqua) and heavy chain (red) (PDB entry [[1sy6]])' scene=''>
+<StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD3 extracellular domain (grey) complex with antibody light chain (aqua) and heavy chain (red) (PDB entry [[1sy6]])' scene=''>
 '''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor.  The CD3 is composed of γ, δ and two ε chains.  These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes.  CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ.  The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM).  Drugs which bind to CD3 are tested as immunorepressants.
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 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-'''CD2 ε chain'''
+'''CD3 ε chain'''
-[[1a81]] – hCD2 ITAM + Syk kinase – human <BR />
+[[1a81]] – hCD3 ITAM + Syk kinase – human <BR />
-[[2k4f]] – mCD2 ITAM – mouse - NMR <BR />
+[[2jxb]] – hCD3 domain SH3-1<br />
-[[3r08]] – mCD2 extracellular domain + antibody<BR />
+[[2k4f]] – mCD3 ITAM – mouse - NMR <BR />
+[[3r08]] – mCD3 extracellular domain + antibody<BR />
-'''CD2 εγ dimer'''
+'''CD3 εγ dimer'''
-[[1jbj]] – hCD2 extracellular domain - NMR<BR />
+[[1jbj]] – hCD3 extracellular domain - NMR<BR />
-[[1sy6]] – hCD2 extracellular domain + antibody<BR />
+[[1sy6]] – hCD3 extracellular domain + antibody<BR />
-'''CD2 εδ dimer'''
+'''CD3 εδ dimer'''
-[[1xiw]] – hCD2 extracellular domain + antibody<BR />
+[[1xiw]] – hCD3 extracellular domain + antibody<BR />
-[[1xmw]] – mCD2 extracellular domain ε/sCD2 extracellular domain δ – sheep<BR />
+[[1xmw]] – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep<BR />
-'''CD2 ζ chain'''
+'''CD3 ζ chain'''
-[[1ygr]], [[2oq1]] – hCD2 ITAM + CD45 protein tyrosine phosphatase <BR />
+[[1ygr]], [[2oq1]] – hCD3 ITAM + CD45 protein tyrosine phosphatase <BR />
-[[3ik5]], [[3ioz]] – hCD2 ITAM + NEF<BR />
+[[3ik5]], [[3ioz]] – hCD3 ITAM + NEF<BR />
-[[2hac]] – hCD2 transmembrane domain - NMR<BR />
+[[2hac]] – hCD3 transmembrane domain - NMR<BR />
+[[Category: Topic Page]]