4cdx: Difference between revisions
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{{STRUCTURE_4cdx| PDB=4cdx | SCENE= }} | |||
===Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor GPP12=== | |||
{{ABSTRACT_PUBMED_22388738}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/B2ZUN0_9ENTO B2ZUN0_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047] | |||
==About this Structure== | |||
[[4cdx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CDX OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:022388738</ref><references group="xtra"/><references/> | |||
[[Category: Colibus, L De.]] | |||
[[Category: Fry, E E.]] | |||
[[Category: Grimes, J.]] | |||
[[Category: Hu, Z.]] | |||
[[Category: Kelly, J.]] | |||
[[Category: Li, X.]] | |||
[[Category: Peng, W.]] | |||
[[Category: Puerstinger, G.]] | |||
[[Category: Rao, Z.]] | |||
[[Category: Ren, J.]] | |||
[[Category: Rowlands, D.]] | |||
[[Category: Spyrou, J A.B.]] | |||
[[Category: Stonehouse, N.]] | |||
[[Category: Stuart, D I.]] | |||
[[Category: Walter, T S.]] | |||
[[Category: Wang, J.]] | |||
[[Category: Wang, X.]] | |||
[[Category: Enterovirus uncoating]] | |||
[[Category: Hand-foot-and-mouth disease]] | |||
[[Category: Inhibitor]] | |||
[[Category: Virus]] | |||
Revision as of 08:06, 13 February 2014
Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor GPP12Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor GPP12
Template:ABSTRACT PUBMED 22388738
FunctionFunction
[B2ZUN0_9ENTO] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
About this StructureAbout this Structure
4cdx is a 4 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Wang X, Peng W, Ren J, Hu Z, Xu J, Lou Z, Li X, Yin W, Shen X, Porta C, Walter TS, Evans G, Axford D, Owen R, Rowlands DJ, Wang J, Stuart DI, Fry EE, Rao Z. A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71. Nat Struct Mol Biol. 2012 Mar 4. doi: 10.1038/nsmb.2255. PMID:22388738 doi:10.1038/nsmb.2255