3vt3: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[3vt3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3vt3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VT3 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:023944708</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:023944708</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Buffalo rat]] | ||
[[Category: Ikura, T.]] | [[Category: Ikura, T.]] | ||
[[Category: Ito, N.]] | [[Category: Ito, N.]] | ||
Revision as of 07:01, 13 February 2014
Crystal structures of rat VDR-LBD with R270L mutationCrystal structures of rat VDR-LBD with R270L mutation
Template:ABSTRACT PUBMED 23944708
FunctionFunction
[VDR_RAT] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.[1]
About this StructureAbout this Structure
3vt3 is a 2 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Nakabayashi M, Tsukahara Y, Iwasaki-Miyamoto Y, Mihori-Shimazaki M, Yamada S, Inaba S, Oda M, Shimizu M, Makishima M, Tokiwa H, Ikura T, Ito N. Crystal Structures of Hereditary Vitamin D-Resistant Rickets-Associated Vitamin D Receptor Mutants R270L and W282R Bound to 1,25-Dihydroxyvitamin D and Synthetic Ligands. J Med Chem. 2013 Aug 29. PMID:23944708 doi:10.1021/jm400537h
- ↑ Vanhooke JL, Tadi BP, Benning MM, Plum LA, DeLuca HF. New analogs of 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 with conformationally restricted side chains: evaluation of biological activity and structural determination of VDR-bound conformations. Arch Biochem Biophys. 2007 Apr 15;460(2):161-5. Epub 2006 Dec 12. PMID:17227670 doi:10.1016/j.abb.2006.11.029