Avidin: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
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[[Image:1ave1.png|left|200px|thumb|Crystal Structure of Chicken Apo-Avidin, [[1ave]]]] | [[Image:1ave1.png|left|200px|thumb|Crystal Structure of Chicken Apo-Avidin, [[1ave]]]] | ||
<applet load='2avi' size='300' frame='true' align='right' caption='Two monomers of the tetramer Avidin complex with biotin (PDB code [[2avi]])' /> | |||
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{{Clear}} | {{Clear}} | ||
The binding affinity of biotin for the avidin <scene name='Sandbox-test/Biotin_binding_avidin/1'>receptors</scene> is very hight or in other words, the strength of the interations between the biotin and the avidin receptors is so strong that washing the biotin-avidin complex is not enough to remove the ligand from its pocket. This is not even possible by adding more biotin molecules to the system avidin-biotin. Once a biotin has bound a pocket in the avidin, it is almost imposible to remove it in a biologica system! | The binding affinity of biotin for the avidin <scene name='Sandbox-test/Biotin_binding_avidin/1'>receptors</scene> is very hight or in other words, the strength of the interations between the biotin and the avidin receptors is so strong that washing the biotin-avidin complex is not enough to remove the ligand from its pocket. This is not even possible by adding more biotin molecules to the system avidin-biotin. Once a biotin has bound a pocket in the avidin, it is almost imposible to remove it in a biologica system! | ||