4j2r: Difference between revisions
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{{STRUCTURE_4j2r| PDB=4j2r | SCENE= }} | |||
===Middle domain of influenza A virus RNA-dependent polymerase PB2=== | |||
{{ABSTRACT_PUBMED_24419622}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PB2_I34A1 PB2_I34A1]] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity). | |||
==About this Structure== | |||
[[4j2r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J2R OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024419622</ref><references group="xtra"/><references/> | |||
[[Category: Hatakeyama, D.]] | |||
[[Category: Kuzuhara, T.]] | |||
[[Category: Qiu, H.]] | |||
[[Category: Tsuge, H.]] | |||
[[Category: Tsumori, Y.]] | |||
[[Category: Tsurumura, T.]] | |||
[[Category: Cap-binding domain]] | |||
[[Category: Cap-snatching]] | |||
[[Category: Viral protein]] | |||
Revision as of 14:18, 5 February 2014
Middle domain of influenza A virus RNA-dependent polymerase PB2Middle domain of influenza A virus RNA-dependent polymerase PB2
Template:ABSTRACT PUBMED 24419622
FunctionFunction
[PB2_I34A1] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).
About this StructureAbout this Structure
4j2r is a 2 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Tsurumura T, Qiu H, Yoshida T, Tsumori Y, Tsuge H. Crystallization and preliminary X-ray diffraction studies of a surface mutant of the middle domain of PB2 from human influenza A (H1N1) virus. Acta Crystallogr F Struct Biol Commun. 2014 Jan;70(Pt 1):72-5. doi:, 10.1107/S2053230X13032603. Epub 2013 Dec 24. PMID:24419622 doi:http://dx.doi.org/10.1107/S2053230X13032603