4c74: Difference between revisions
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{{STRUCTURE_4c74| PDB=4c74 | SCENE= }} | |||
===Phenylacetone monooxygenase: Reduced enzyme in complex with APADP=== | |||
{{ABSTRACT_PUBMED_24443704}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PAMO_THEFY PAMO_THEFY]] Catalyzes a Baeyer-Villiger oxidation reaction, i.e. the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Is most efficient with phenylacetone as substrate, leading to the formation of benzyl acetate. Can also oxidize other aromatic ketones (benzylacetone, alpha-methylphenylacetone and 4-hydroxyacetophenone), some aliphatic ketones (dodecan-2-one and bicyclohept-2-en-6-one) and sulfides (e.g. methyl 4-tolylsulfide). | |||
==About this Structure== | |||
[[4c74]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C74 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024443704</ref><references group="xtra"/><references/> | |||
[[Category: Phenylacetone monooxygenase]] | |||
[[Category: Fraaije, M W.]] | |||
[[Category: Martinoli, C.]] | |||
[[Category: Mattevi, A.]] | |||
[[Category: Baeyer-villiger]] | |||
[[Category: Cofactor]] | |||
[[Category: Flavin]] | |||
[[Category: Oxidoreductase]] | |||
Revision as of 14:16, 5 February 2014
Phenylacetone monooxygenase: Reduced enzyme in complex with APADPPhenylacetone monooxygenase: Reduced enzyme in complex with APADP
Template:ABSTRACT PUBMED 24443704
FunctionFunction
[PAMO_THEFY] Catalyzes a Baeyer-Villiger oxidation reaction, i.e. the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Is most efficient with phenylacetone as substrate, leading to the formation of benzyl acetate. Can also oxidize other aromatic ketones (benzylacetone, alpha-methylphenylacetone and 4-hydroxyacetophenone), some aliphatic ketones (dodecan-2-one and bicyclohept-2-en-6-one) and sulfides (e.g. methyl 4-tolylsulfide).
About this StructureAbout this Structure
4c74 is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Martinoli C, Dudek HM, Orru R, Edmondson DE, Fraaije MW, Mattevi A. Beyond the Protein Matrix: Probing Cofactor Variants in a Baeyer-Villiger Oxygenation Reaction. ACS Catal. 2013;3(12):3058-3062. PMID:24443704 doi:http://dx.doi.org/10.1021/cs400837z