4jsc: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[4jsc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4jsc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JSC OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:023808545</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:023808545</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: African clawed frog]] | ||
[[Category: Graves, B.]] | [[Category: Graves, B.]] | ||
[[Category: Janson, C A.]] | [[Category: Janson, C A.]] | ||
Revision as of 12:36, 5 February 2014
The 2.5A crystal structure of humanized Xenopus MDM2 with RO5316533 - a pyrrolidine MDM2 inhibitorThe 2.5A crystal structure of humanized Xenopus MDM2 with RO5316533 - a pyrrolidine MDM2 inhibitor
Template:ABSTRACT PUBMED 23808545
FunctionFunction
[MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).
About this StructureAbout this Structure
4jsc is a 2 chain structure with sequence from African clawed frog. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Ding Q, Zhang Z, Liu JJ, Jiang N, Zhang J, Ross TM, Chu XJ, Bartkovitz D, Podlaski F, Janson C, Tovar C, Filipovic ZM, Higgins B, Glenn K, Packman K, Vassilev LT, Graves B. Discovery of RG7388, a Potent and Selective p53-MDM2 Inhibitor in Clinical Development. J Med Chem. 2013 Jul 16. PMID:23808545 doi:10.1021/jm400487c