2xfh: Difference between revisions

Revision as of 11:04, 5 February 2014

Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.

Template:ABSTRACT PUBMED 20845962

About this StructureAbout this Structure

2xfh is a 1 chain structure with sequence from "actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923. This structure supersedes the now removed PDB entry 2vrv. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Montemiglio LC, Gianni S, Vallone B, Savino C. Azole drugs trap cytochrome P450 EryK in alternative conformational states. Biochemistry. 2010 Sep 16. PMID:20845962 doi:10.1021/bi101062v

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OCA

[1] Montemiglio LC, Gianni S, Vallone B, Savino C. Azole drugs trap cytochrome P450 EryK in alternative conformational states. Biochemistry. 2010 Sep 16. PMID:20845962 doi:10.1021/bi101062v

[xtra 1]

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 {{STRUCTURE_2xfh|  PDB=2xfh  |  SCENE=  }}
-===STRUCTURE OF CYTOCHROME P450 ERYK COCRYSTALLIZED WITH INHIBITOR CLOTRIMAZOLE.===
+===Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.===
 {{ABSTRACT_PUBMED_20845962}}
-==Function==
-[[http://www.uniprot.org/uniprot/CPXQ_SACEN CPXQ_SACEN]] Responsible for the C-12 hydroxylation of the macrolactone ring of erythromycin. Thus, EryK catalyzes the hydroxylation of erythromycin D (ErD) at the C-12 position to produce erythromycin C (ErC). Erythromycin B (ErB) is not a substrate for this enzyme.<ref>PMID:8416893</ref> <ref>PMID:7849045</ref>
 ==About this Structure==
-[[2xfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA].
+[[2xfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vrv 2vrv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA].
 ==Reference==
 <ref group="xtra">PMID:020845962</ref><references group="xtra"/><references/>
-[[Category: Saccharopolyspora erythraea]]
 [[Category: Gianni, S.]]
 [[Category: Montemiglio, L C.]]