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{{STRUCTURE_3arf| PDB=3arf | SCENE= }} | {{STRUCTURE_3arf| PDB=3arf | SCENE= }} | ||
===Ternary crystal structure of the mouse NKT TCR-CD1d-C20:2=== | ===Ternary crystal structure of the mouse NKT TCR-CD1d-C20:2=== | ||
{{ABSTRACT_PUBMED_21376639}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref> [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | |||
==About this Structure== | ==About this Structure== | ||
[[3arf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3arf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ARF OCA]. | ||
==See Also== | ==See Also== | ||
*[[Beta-2 microglobulin|Beta-2 microglobulin]] | *[[Beta-2 microglobulin|Beta-2 microglobulin]] | ||
*[[CD1|CD1]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021376639</ref><references group="xtra"/> | <ref group="xtra">PMID:021376639</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: Rossjohn, J.]] | [[Category: Rossjohn, J.]] | ||
[[Category: Wun, K S.]] | [[Category: Wun, K S.]] | ||
Revision as of 09:28, 29 January 2014
Ternary crystal structure of the mouse NKT TCR-CD1d-C20:2Ternary crystal structure of the mouse NKT TCR-CD1d-C20:2
Template:ABSTRACT PUBMED 21376639
FunctionFunction
[CD1D1_MOUSE] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.[1] [2] [3] [B2MG_MOUSE] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
About this StructureAbout this Structure
3arf is a 4 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Wun KS, Cameron G, Patel O, Pang SS, Pellicci DG, Sullivan LC, Keshipeddy S, Young MH, Uldrich AP, Thakur MS, Richardson SK, Howell AR, Illarionov PA, Brooks AG, Besra GS, McCluskey J, Gapin L, Porcelli SA, Godfrey DI, Rossjohn J. A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T Cells. Immunity. 2011 Mar 25;34(3):327-39. Epub 2011 Mar 3. PMID:21376639 doi:10.1016/j.immuni.2011.02.001
- ↑ Jayawardena-Wolf J, Benlagha K, Chiu YH, Mehr R, Bendelac A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity. 2001 Dec;15(6):897-908. PMID:11754812
- ↑ Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. J Exp Med. 2005 Dec 5;202(11):1517-26. Epub 2005 Nov 28. PMID:16314439 doi:10.1084/jem.20051625
- ↑ Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:16007091 doi:10.1038/ni1224