Chloride Intracellular Channel Protein 2: Difference between revisions
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<StructureSection load='2r5g' size='450' side='right' scene='Chloride_Intracellular_Channel_Protein_2/Structintro/2' caption=''> | <StructureSection load='2r5g' size='450' side='right' scene='Chloride_Intracellular_Channel_Protein_2/Structintro/2' caption='Human CLIC2 (PDB code [[2r5g]])'> | ||
[[Image:Nfig001.jpg|300px|left|thumb| Localization of the different structures of CLIC2]] | [[Image:Nfig001.jpg|300px|left|thumb| Localization of the different structures of CLIC2]] | ||
CLIC proteins are a new class of soluble and membrane-bound proteins that have been grouped together on the basis of their sequence similarity. The proteins were named CLIC because the first members of this family to be characterized formed intracellular chloride channels. <ref>PMID:9339381</ref> They display broad tissue and cellular distribution. They have been implicated in kidney function, cell division, and bone resorption. <ref>PMID:18007051</ref> They differ from the other classes of chloride ion channels in primary structure and in the transmembrane regions of the tertiary structure. Since the first member of CLIC, p64 (CLIC5), was discovered in bovine kidney, several members of the CLIC family have been found in other tissues from many species, including NCC27 (CLIC1), CLIC2, CLIC3, mtCLIC (CLIC4), and parchorin (CLIC6). <ref>PMID:19356589</ref> With the exception of p64 and parchorin, these proteins contain a conserved region of approximately 240 residues. <ref>PMID:17945253 </ref> | CLIC proteins are a new class of soluble and membrane-bound proteins that have been grouped together on the basis of their sequence similarity. The proteins were named CLIC because the first members of this family to be characterized formed intracellular chloride channels. <ref>PMID:9339381</ref> They display broad tissue and cellular distribution. They have been implicated in kidney function, cell division, and bone resorption. <ref>PMID:18007051</ref> They differ from the other classes of chloride ion channels in primary structure and in the transmembrane regions of the tertiary structure. Since the first member of CLIC, p64 (CLIC5), was discovered in bovine kidney, several members of the CLIC family have been found in other tissues from many species, including NCC27 (CLIC1), CLIC2, CLIC3, mtCLIC (CLIC4), and parchorin (CLIC6). <ref>PMID:19356589</ref> With the exception of p64 and parchorin, these proteins contain a conserved region of approximately 240 residues. <ref>PMID:17945253 </ref> | ||