4c3e: Difference between revisions
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{{STRUCTURE_4c3e| PDB=4c3e | SCENE= }} | |||
===HRSV M2-1 mutant S58D S61D, P21 crystal=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/M21_HRSVA M21_HRSVA]] Acts as a transcriptional elongation factor to prevent premature termination during transcription thus allowing complete synthesis of RSV mRNAs. Functions also as a processivity and antitermination factor to permit transit of the polymerase through intergenic regions to access promoter distal genes. Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Also, can activate NF-kappa-B through association with host RELA.<ref>PMID:8552680</ref> <ref>PMID:9420254</ref> <ref>PMID:10364337</ref> | |||
==About this Structure== | |||
[[4c3e]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C3E OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Ariza, A.]] | |||
[[Category: Barr, J N.]] | |||
[[Category: Carroll, M W.]] | |||
[[Category: Edwards, T A.]] | |||
[[Category: Eleouet, J F.]] | |||
[[Category: Hiscox, J A.]] | |||
[[Category: Richard, C A.]] | |||
[[Category: Silman, N J.]] | |||
[[Category: Tanner, S J.]] | |||
[[Category: Trincao, J.]] | |||
[[Category: Wu, W.]] | |||
[[Category: Viral protein]] | |||
Revision as of 10:01, 22 January 2014
HRSV M2-1 mutant S58D S61D, P21 crystalHRSV M2-1 mutant S58D S61D, P21 crystal
FunctionFunction
[M21_HRSVA] Acts as a transcriptional elongation factor to prevent premature termination during transcription thus allowing complete synthesis of RSV mRNAs. Functions also as a processivity and antitermination factor to permit transit of the polymerase through intergenic regions to access promoter distal genes. Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Also, can activate NF-kappa-B through association with host RELA.[1] [2] [3]
About this StructureAbout this Structure
4c3e is a 16 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Collins PL, Hill MG, Cristina J, Grosfeld H. Transcription elongation factor of respiratory syncytial virus, a nonsegmented negative-strand RNA virus. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):81-5. PMID:8552680
- ↑ Hardy RW, Wertz GW. The product of the respiratory syncytial virus M2 gene ORF1 enhances readthrough of intergenic junctions during viral transcription. J Virol. 1998 Jan;72(1):520-6. PMID:9420254
- ↑ Fearns R, Collins PL. Role of the M2-1 transcription antitermination protein of respiratory syncytial virus in sequential transcription. J Virol. 1999 Jul;73(7):5852-64. PMID:10364337