4ma8: Difference between revisions
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{{STRUCTURE_4ma8| PDB=4ma8 | SCENE= }} | |||
===Crystal structure of mouse prion protein complexed with Chlorpromazine=== | |||
{{ABSTRACT_PUBMED_24373770}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.<ref>PMID:12732622</ref> <ref>PMID:16492732</ref> <ref>PMID:19242475</ref> <ref>PMID:19568430</ref> | |||
==About this Structure== | |||
[[4ma8]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MA8 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024373770</ref><references group="xtra"/><references/> | |||
[[Category: Baral, P K.]] | |||
[[Category: James, M N.G.]] | |||
[[Category: Swayampakula, M.]] | |||
[[Category: Antibody]] | |||
[[Category: Fab]] | |||
[[Category: Immune system]] | |||
[[Category: Immunoglobulin fold]] | |||
[[Category: Mouse prion protein]] | |||