2zb0: Difference between revisions
New page: left|200px<br /><applet load="2zb0" size="350" color="white" frame="true" align="right" spinBox="true" caption="2zb0, resolution 2.100Å" /> '''Crystal structure o... |
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==Overview== | ==Overview== | ||
The biphenyl amides (BPAs) are a novel series of p38 MAP kinase | The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Mitogen-activated protein kinase]] | [[Category: Mitogen-activated protein kinase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Somers, D | [[Category: Somers, D O.]] | ||
[[Category: GK3]] | [[Category: GK3]] | ||
[[Category: GOL]] | [[Category: GOL]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:01:12 2008'' | ||
Revision as of 20:01, 21 February 2008
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Crystal structure of P38 in complex with biphenyl amide inhibitor
OverviewOverview
The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.
About this StructureAbout this Structure
2ZB0 is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Mitogen-activated protein kinase, with EC number 2.7.11.24 Full crystallographic information is available from OCA.
ReferenceReference
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:18006306
Page seeded by OCA on Thu Feb 21 19:01:12 2008