3a28: Difference between revisions
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{{STRUCTURE_3a28| PDB=3a28 | SCENE= }} | {{STRUCTURE_3a28| PDB=3a28 | SCENE= }} | ||
===Crystal structure of L-2,3-butanediol dehydrogenase=== | ===Crystal structure of L-2,3-butanediol dehydrogenase=== | ||
{{ABSTRACT_PUBMED_19941855}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BUDC_CORGT BUDC_CORGT]] Catalyzes the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol (L-BD) in the presence of NADH. To a lesser extent, can also catalyze the irreversible reduction of diacetyl to (S)-acetoin. Cannot oxidize meso-BD, D-BD, 2-butanol, 1,2-propanediol, ethanol, acetol, 1,2-butanediol, 1,3-butanediol, n-butanol, and n-propanol. Cannot reduce (R)-acetoin, acetol, dihydroxyacetone and 2,4-pentanedione.[REFERENCE:1]<ref>PMID:11577733</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3a28]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3a28]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A28 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019941855</ref><references group="xtra"/> | <ref group="xtra">PMID:019941855</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Micrococcus glutamicus kinoshita et al. 1958]] | ||
[[Category: Kurisu, G.]] | [[Category: Kurisu, G.]] | ||
[[Category: Kusunoki, M.]] | [[Category: Kusunoki, M.]] | ||
Revision as of 09:22, 22 January 2014
Crystal structure of L-2,3-butanediol dehydrogenaseCrystal structure of L-2,3-butanediol dehydrogenase
Template:ABSTRACT PUBMED 19941855
FunctionFunction
[BUDC_CORGT] Catalyzes the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol (L-BD) in the presence of NADH. To a lesser extent, can also catalyze the irreversible reduction of diacetyl to (S)-acetoin. Cannot oxidize meso-BD, D-BD, 2-butanol, 1,2-propanediol, ethanol, acetol, 1,2-butanediol, 1,3-butanediol, n-butanol, and n-propanol. Cannot reduce (R)-acetoin, acetol, dihydroxyacetone and 2,4-pentanedione.[REFERENCE:1][1]
About this StructureAbout this Structure
3a28 is a 8 chain structure with sequence from "micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Otagiri M, Ui S, Takusagawa Y, Ohtsuki T, Kurisu G, Kusunoki M. Structural basis for chiral substrate recognition by two 2,3-butanediol dehydrogenases. FEBS Lett. 2010 Jan 4;584(1):219-23. Epub . PMID:19941855 doi:10.1016/j.febslet.2009.11.068