2m1w: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_2m1w|  PDB=2m1w  |  SCENE=  }}
===TICAM-2 TIR domain===
{{ABSTRACT_PUBMED_24255114}}


The entry 2m1w is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/TCAM2_HUMAN TCAM2_HUMAN]] Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.<ref>PMID:12721283</ref> <ref>PMID:14519765</ref> <ref>PMID:14517278</ref> <ref>PMID:194121844</ref> <ref>PMID:16603631</ref> <ref>PMID:16757566</ref> <ref>PMID:22685567</ref>  Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.<ref>PMID:12721283</ref> <ref>PMID:14519765</ref> <ref>PMID:14517278</ref> <ref>PMID:194121844</ref> <ref>PMID:16603631</ref> <ref>PMID:16757566</ref> <ref>PMID:22685567</ref>  


Authors: Enokizono, Y., Kumeta, H., Funami, K., Horiuchi, M., Sarmiento, J., Yamashita, K., Standley, D.M., Matsumoto, M., Seya, T., Inagaki, F.
==About this Structure==
[[2m1w]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M1W OCA].  


Description: TICAM-2 TIR domain
==Reference==
<ref group="xtra">PMID:024255114</ref><references group="xtra"/><references/>
[[Category: Enokizono, Y.]]
[[Category: Funami, K.]]
[[Category: Horiuchi, M.]]
[[Category: Inagaki, F.]]
[[Category: Kumeta, H.]]
[[Category: Matsumoto, M.]]
[[Category: Sarmiento, J.]]
[[Category: Seya, T.]]
[[Category: Standley, D M.]]
[[Category: Yamashita, K.]]
[[Category: Immune system]]
[[Category: Innate immunity]]
[[Category: Interferon]]
[[Category: Ticam-2]]
[[Category: Tir domain]]
[[Category: Tram]]

Revision as of 11:17, 15 January 2014

Template:STRUCTURE 2m1w

TICAM-2 TIR domainTICAM-2 TIR domain

Template:ABSTRACT PUBMED 24255114

FunctionFunction

[TCAM2_HUMAN] Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.[1] [2] [3] [4] [5] [6] [7] Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.[8] [9] [10] [11] [12] [13] [14]

About this StructureAbout this Structure

2m1w is a 1 chain structure. Full experimental information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Enokizono Y, Kumeta H, Funami K, Horiuchi M, Sarmiento J, Yamashita K, Standley DM, Matsumoto M, Seya T, Inagaki F. Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19908-13. doi:, 10.1073/pnas.1222811110. Epub 2013 Nov 19. PMID:24255114 doi:http://dx.doi.org/10.1073/pnas.1222811110
  1. ↑ Bin LH, Xu LG, Shu HB. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J Biol Chem. 2003 Jul 4;278(27):24526-32. Epub 2003 Apr 28. PMID:12721283 doi:http://dx.doi.org/10.1074/jbc.M303451200
  2. ↑ Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T. TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem. 2003 Dec 12;278(50):49751-62. Epub 2003 Sep 30. PMID:14519765 doi:http://dx.doi.org/10.1074/jbc.M305820200
  3. ↑ Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med. 2003 Oct 6;198(7):1043-55. Epub 2003 Sep 29. PMID:14517278 doi:http://dx.doi.org/10.1084/jem.20031023
  4. ↑ . PMID:194121844
  5. ↑ Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'Neill LA, Fitzgerald KA, Golenbock DT. The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6299-304. Epub 2006 Apr 7. PMID:16603631 doi:http://dx.doi.org/10.1073/pnas.0510041103
  6. ↑ McGettrick AF, Brint EK, Palsson-McDermott EM, Rowe DC, Golenbock DT, Gay NJ, Fitzgerald KA, O'Neill LA. Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9196-201. Epub 2006 Jun 6. PMID:16757566 doi:http://dx.doi.org/10.1073/pnas.0600462103
  7. ↑ Ohnishi H, Tochio H, Kato Z, Kawamoto N, Kimura T, Kubota K, Yamamoto T, Funasaka T, Nakano H, Wong RW, Shirakawa M, Kondo N. TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88. PLoS One. 2012;7(6):e38423. doi: 10.1371/journal.pone.0038423. Epub 2012 Jun 7. PMID:22685567 doi:http://dx.doi.org/10.1371/journal.pone.0038423
  8. ↑ Bin LH, Xu LG, Shu HB. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J Biol Chem. 2003 Jul 4;278(27):24526-32. Epub 2003 Apr 28. PMID:12721283 doi:http://dx.doi.org/10.1074/jbc.M303451200
  9. ↑ Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T. TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem. 2003 Dec 12;278(50):49751-62. Epub 2003 Sep 30. PMID:14519765 doi:http://dx.doi.org/10.1074/jbc.M305820200
  10. ↑ Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med. 2003 Oct 6;198(7):1043-55. Epub 2003 Sep 29. PMID:14517278 doi:http://dx.doi.org/10.1084/jem.20031023
  11. ↑ . PMID:194121844
  12. ↑ Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'Neill LA, Fitzgerald KA, Golenbock DT. The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6299-304. Epub 2006 Apr 7. PMID:16603631 doi:http://dx.doi.org/10.1073/pnas.0510041103
  13. ↑ McGettrick AF, Brint EK, Palsson-McDermott EM, Rowe DC, Golenbock DT, Gay NJ, Fitzgerald KA, O'Neill LA. Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9196-201. Epub 2006 Jun 6. PMID:16757566 doi:http://dx.doi.org/10.1073/pnas.0600462103
  14. ↑ Ohnishi H, Tochio H, Kato Z, Kawamoto N, Kimura T, Kubota K, Yamamoto T, Funasaka T, Nakano H, Wong RW, Shirakawa M, Kondo N. TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88. PLoS One. 2012;7(6):e38423. doi: 10.1371/journal.pone.0038423. Epub 2012 Jun 7. PMID:22685567 doi:http://dx.doi.org/10.1371/journal.pone.0038423

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