2mak: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_2mak|  PDB=2mak  |  SCENE=  }}
+===Solution structure of the STIM1 CC1-CC2 homodimer in complex with two Orai1 C-terminal domains.===
+{{ABSTRACT_PUBMED_24351972}}
-The entry 2mak is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/STIM1_HUMAN STIM1_HUMAN]] Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) [MIM:[http://omim.org/entry/612783 612783]]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.<ref>PMID:19420366</ref>  [[http://www.uniprot.org/uniprot/CRCM1_HUMAN CRCM1_HUMAN]] Combined immunodeficiency due to ORAI1 deficiency. The disease is caused by mutations affecting the gene represented in this entry.
-Authors: Stathopulos, P.B., Ikura, M.
+==Function==
+[[http://www.uniprot.org/uniprot/STIM1_HUMAN STIM1_HUMAN]] Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.<ref>PMID:9377559</ref> <ref>PMID:16005298</ref> <ref>PMID:15866891</ref> <ref>PMID:16208375</ref> <ref>PMID:16807233</ref> <ref>PMID:16766533</ref> <ref>PMID:16733527</ref> <ref>PMID:16537481</ref> <ref>PMID:22464749</ref>  [[http://www.uniprot.org/uniprot/CRCM1_HUMAN CRCM1_HUMAN]] Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.<ref>PMID:16766533</ref> <ref>PMID:16807233</ref> <ref>PMID:16733527</ref> <ref>PMID:16645049</ref> <ref>PMID:16582901</ref>
-Description: Solution structure of the STIM1 CC1-CC2 homodimer in complex with two Orai1 C-terminal domains.
+==About this Structure==
+[[2mak]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MAK OCA].
+==Reference==
+<ref group="xtra">PMID:024351972</ref><references group="xtra"/><references/>
+[[Category: Ikura, M.]]
+[[Category: Stathopulos, P B.]]
+[[Category: Coiled-coil]]
+[[Category: Orai1]]
+[[Category: Orai1 c-terminal domain]]
+[[Category: Signaling protein-transport protein complex]]
+[[Category: Stim1]]
+[[Category: Transport protein]]