4jgm: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4jgm|  PDB=4jgm  |  SCENE=  }}
+===Crystal structure of RelB double mutants: Y300F/I335V===
+{{ABSTRACT_PUBMED_23485337}}
-The entry 4jgm is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/RELB_MOUSE RELB_MOUSE]] NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.<ref>PMID:22565310</ref>
-Authors: Huang, D.B., Vu, D., Ghosh, G.
+==About this Structure==
+[[4jgm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGM OCA].
-Description: Crystal structure of RelB double mutants: Y300F/I335V
+==Reference==
+<ref group="xtra">PMID:023485337</ref><references group="xtra"/><references/>
+[[Category: Ghosh, G.]]
+[[Category: Huang, D B.]]
+[[Category: Vu, D.]]
+[[Category: Intertwined dimer]]
+[[Category: Side-by side dimer]]
+[[Category: Transcription]]
+[[Category: Transcription factor]]