4bae: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[4bae]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4bae]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_smegmatis"_trevisan_1889 "bacillus smegmatis" trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BAE OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024126580</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024126580</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Bacillus smegmatis trevisan 1889]] | ||
[[Category: Gingell, H G.]] | [[Category: Gingell, H G.]] | ||
[[Category: Madhavapeddi, P.]] | [[Category: Madhavapeddi, P.]] | ||
Revision as of 10:09, 15 January 2014
Optimisation of pyrroleamides as mycobacterial GyrB ATPase inhibitors: Structure Activity Relationship and in vivo efficacy in the mouse model of tuberculosisOptimisation of pyrroleamides as mycobacterial GyrB ATPase inhibitors: Structure Activity Relationship and in vivo efficacy in the mouse model of tuberculosis
Template:ABSTRACT PUBMED 24126580
FunctionFunction
[GYRB_MYCSM] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
About this StructureAbout this Structure
4bae is a 4 chain structure with sequence from "bacillus_smegmatis"_trevisan_1889 "bacillus smegmatis" trevisan 1889. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Hameed SP, Solapure S, Mukherjee K, Nandi V, Waterson D, Shandil R, Balganesh M, Sambandamurthy VK, Raichurkar AK, Deshpande A, Ghosh A, Awasthy D, Shanbhag G, Sheikh G, McMiken H, Puttur J, Reddy J, Werngren J, Read J, Kumar M, R M, Chinnapattu M, Madhavapeddi P, Manjrekar P, Basu R, Gaonkar S, Sharma S, Hoffner S, Humnabadkar V, Subbulakshmi V, Panduga V. Optimization of pyrrolamides as mycobacterial GyrB ATPase inhibitors: Structure Activity Relationship and in vivo efficacy in the mouse model of tuberculosis. Antimicrob Agents Chemother. 2013 Oct 14. PMID:24126580 doi:http://dx.doi.org/10.1128/AAC.01751-13