4myq: Difference between revisions
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{{STRUCTURE_4myq| PDB=4myq | SCENE= }} | {{STRUCTURE_4myq| PDB=4myq | SCENE= }} | ||
===Selective Inhibition of the Catalytic Domain Of Human Phosphodiesterase 4B With A-33=== | ===Selective Inhibition of the Catalytic Domain Of Human Phosphodiesterase 4B With A-33=== | ||
{{ABSTRACT_PUBMED_24361374}} | |||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <ref group="xtra">PMID:024361374</ref><references group="xtra"/><references/> | ||
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]] | [[Category: 3',5'-cyclic-nucleotide phosphodiesterase]] | ||
[[Category: Edwards, T E.]] | [[Category: Edwards, T E.]] | ||
Revision as of 09:55, 15 January 2014
Selective Inhibition of the Catalytic Domain Of Human Phosphodiesterase 4B With A-33Selective Inhibition of the Catalytic Domain Of Human Phosphodiesterase 4B With A-33
Template:ABSTRACT PUBMED 24361374
FunctionFunction
[PDE4B_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.[1] [2]
About this StructureAbout this Structure
4myq is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Fox D 3rd, Burgin AB, Gurney ME. Structural basis for the design of selective phosphodiesterase 4B inhibitors. Cell Signal. 2013 Dec 19;26(3):657-663. doi: 10.1016/j.cellsig.2013.12.003. PMID:24361374 doi:http://dx.doi.org/10.1016/j.cellsig.2013.12.003
- ↑ Xu RX, Hassell AM, Vanderwall D, Lambert MH, Holmes WD, Luther MA, Rocque WJ, Milburn MV, Zhao Y, Ke H, Nolte RT. Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity. Science. 2000 Jun 9;288(5472):1822-5. PMID:10846163
- ↑ Xu RX, Rocque WJ, Lambert MH, Vanderwall DE, Luther MA, Nolte RT. Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. J Mol Biol. 2004 Mar 19;337(2):355-65. PMID:15003452 doi:http://dx.doi.org/10.1016/j.jmb.2004.01.040