Sandbox Reserved 815: Difference between revisions
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=Introduction= | |||
[[Image:3haf bio r 500.jpg|left|220px|thumb|'''3HAF Domain-Dimer''']] | [[Image:3haf bio r 500.jpg|left|220px|thumb|'''3HAF Domain-Dimer''']] | ||
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=Structure of 3HAF domain of Human Prion= | |||
The 3HAF structure results from a work leaded by Lee S. in 2010, in which they have characterized seven variants of the human prion. The structure was determined by XRAY diffraction in a 2.26-Angstrom resolution. | The 3HAF structure results from a work leaded by Lee S. in 2010, in which they have characterized seven variants of the human prion. The structure was determined by XRAY diffraction in a 2.26-Angstrom resolution. | ||
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= Ligand and interactions = | |||
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= Repercussion of the M129/V129 polymorphism = | |||
It’s known that the transformation of the normal protein in its infectious model involves a conversion from a soluble and predominantly α-helical protein to an aggregated form, which is substantially enriched in β-sheet. | It’s known that the transformation of the normal protein in its infectious model involves a conversion from a soluble and predominantly α-helical protein to an aggregated form, which is substantially enriched in β-sheet. | ||
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=See Also= | |||
*[[Prion|Prion]] | *[[Prion|Prion]] | ||
*[http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=3haf&template=main.html PDBSum] | *[http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=3haf&template=main.html PDBSum] | ||
*[http://www.ebi.ac.uk/pdbe-srv/view/entry/3haf/summary.html EMBISum] | *[http://www.ebi.ac.uk/pdbe-srv/view/entry/3haf/summary.html EMBISum] | ||
=Reference= | |||
<ref group="xtra">PMID:019927125</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:019927125</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||