Sandbox Reserved 817: Difference between revisions
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=== Localisation === | === Localisation === | ||
BACE1 is the result of the expression of the BACE1 gene localised on chromosome 11 (30kb). This gene is composed of 9 exons that are linked together during the mRNA maturation. BACE1 is expressed in the majority of human tissues however, the highest levels of activity are found in the neuronal cell. This β secretase is a transmembrane protein mainly localised within cholesterol-rich lipid raft. It is found in the acidic compartments of the secretory pathway (mostly endosomes and the Trans Golgi Network) with its catalytic site facing the lumen side. This enzyme is regulated both at the translation and transcription steps and its expression is correlated with cell stress signals.<ref=name"un">PMID: 18005427</ref> | BACE1 is the result of the expression of the BACE1 gene localised on chromosome 11 (30kb). This gene is composed of 9 exons that are linked together during the mRNA maturation. BACE1 is expressed in the majority of human tissues however, the highest levels of activity are found in the neuronal cell. This β secretase is a transmembrane protein mainly localised within cholesterol-rich lipid raft. It is found in the acidic compartments of the secretory pathway (mostly endosomes and the Trans Golgi Network) with its catalytic site facing the lumen side. This enzyme is regulated both at the translation and transcription steps and its expression is correlated with cell stress signals.<ref=name"un">PMID:18005427</ref> | ||
=== Post translational modification === | === Post translational modification === | ||