Sandbox Reserved 817: Difference between revisions
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BACE1 is synthetised in the endoplasmamic reticulum as an inactive precursor, pro-BACE1. This precursor is then maturated in the Golgi apparatus. It undergoes glycosylation of 4 residues : <scene name='56/568015/Asn/1'>Asn(153), Asn(172), Asn(223) and Asn(354) </scene>. This has a role in the activity of BACE1. 3 cysteine residues of the cytosolic tail are also palmitoylated , it is has a role in the localization of the mature enzyme. The propeptide domain is then clived between Arg 45 and Glu 46 of pro-BACE1 by a proprotein convertase (protease). This clivage is known to increase the activity of the enzyme. | BACE1 is synthetised in the endoplasmamic reticulum as an inactive precursor, pro-BACE1. This precursor is then maturated in the Golgi apparatus. It undergoes glycosylation of 4 residues : <scene name='56/568015/Asn/1'>Asn(153), Asn(172), Asn(223) and Asn(354) </scene>. This has a role in the activity of BACE1. 3 cysteine residues of the cytosolic tail are also palmitoylated , it is has a role in the localization of the mature enzyme. The propeptide domain is then clived between Arg 45 and Glu 46 of pro-BACE1 by a proprotein convertase (protease). This clivage is known to increase the activity of the enzyme. | ||
[[Image:APP cleavage at beta and alpha site.png|right|400px|thumb|'''Figure 1 :''' | [[Image:APP cleavage at beta and alpha site.png|right|400px|thumb|'''Figure 1 :''' Cleavage of APP by the amyloidogenic and non amyloidogenic pathways '']] | ||
=== Biological functions === | === Biological functions === | ||