Sandbox Reserved 818: Difference between revisions
Paul Giroud (talk | contribs) No edit summary |
Paul Giroud (talk | contribs) No edit summary |
||
| Line 80: | Line 80: | ||
These observations imply that the holotoxin traffics via the endosomal pathway and Golgi apparatus to the endoplasmic reticulum, where it meet ATP and disulphide isomerase, leading to the release of the S1 subunit. S1 then translocate directly through the endoplasmic reticulum membrane into the cytosol. | These observations imply that the holotoxin traffics via the endosomal pathway and Golgi apparatus to the endoplasmic reticulum, where it meet ATP and disulphide isomerase, leading to the release of the S1 subunit. S1 then translocate directly through the endoplasmic reticulum membrane into the cytosol. | ||
<applet load="1bcp" size="300" color="white" frame="true" align="right" caption="PTX bound to ATP : [[1bcp]]" scene=56/568016/Ptx_atp/ | <applet load="1bcp" size="300" color="white" frame="true" align="right" caption="PTX bound to ATP : [[1bcp]]" scene=56/568016/Ptx_atp/2 /> | ||
==Mechanism of pertussis toxin== | ==Mechanism of pertussis toxin== | ||