Sandbox Reserved 826: Difference between revisions

A main characteristic of cancerous cells is the dysregulation of  the cell cycle allowing uncontrolled cell growth and proliferation while safety mechanisms as senescence and apoptosis are inhibited. As the activation of the CDK4 pathway leads to transition from the G1 to the S phase of the cell-cycle via the inhibition of the retinoblastoma protein, this pathway plays an important role in cancerogenesis. In accordance with this idea, the CDK4 pathway was found to be altered in regulation in about 90% of studied melanomas <ref> PMID: 24089445 </ref>. In case of cancer variants where the dysregulation of the CDK4 signalling pathway is the main reason for melanoma development and not a secondary effect, drugs that target and inhibit CDK4 might be very promising. Therefore, further studies should be undertaken to develop new therapeutic agents fighting cancer at this central point of cell-cycle regulation.