Sandbox Reserved 817: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Adrien Mahler-Wohlgemuth

@@ Line 18: / Line 18: @@
 === Post translational modification ===
-BACE1 is synthetised in the endoplasmamic reticulum as a precursor, pro BACE1 and it is inactive. This precursor is then maturated in the Golgi apparatus. It undergoes glycosylation of 4 residus : <scene name='56/568015/Asn153/1'>Asn(153)</scene> ,<scene name='56/568015/Asn172/1'>Asn(172)</scene> , <scene name='56/568015/Asn223/1'>Asn(223)</scene>, and <scene name='56/568015/Asn354/2'>Asn(354)</scene>, it has a role in activity. 3 cysteine residues of the cytosolic tail are also palmitoylated , it is has a role in the localization of the mature enzyme. The propeptide domain is clived between Arg 45 and Glu 46 by a proprotein convertase (protease). This clivage is known to increase the activity of the enzyme.
+BACE1 is synthetised in the endoplasmamic reticulum as a precursor, pro BACE1 and it is inactive. This precursor is then maturated in the Golgi apparatus. It undergoes glycosylation of 4 residus : <scene name='56/568015/Asn/1'>Asn(153), Asn(172), Asn(223) and Asn(354) </scene> it has a role in activity. 3 cysteine residues of the cytosolic tail are also palmitoylated , it is has a role in the localization of the mature enzyme. The propeptide domain is clived between Arg 45 and Glu 46 by a proprotein convertase (protease). This clivage is known to increase the activity of the enzyme.
 [[Image:App cleavage.png|right|400px|thumb|'''Figure 1 :''' cleavage of APP by the amyloidogenic and non amyloidogenic pathways'']]