Sandbox Reserved 817: Difference between revisions

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Revision as of 14:47, 8 January 2014 view source Adrien Mahler-Wohlgemuth (talk \| contribs) 114 edits No edit summary ← Older edit		Revision as of 14:49, 8 January 2014 view source Adrien Mahler-Wohlgemuth (talk \| contribs) 114 edits No edit summary Newer edit →
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	It is interesting to note that APP can also be cleaved by α-secretase but, as it does not produce β-amyloid, it is said that it is a non-amyloidogenic pathway (contrary to the amyloidogenic pathway induced by BACE1).		It is interesting to note that APP can also be cleaved by α-secretase but, as it does not produce β-amyloid, it is said that it is a non-amyloidogenic pathway (contrary to the amyloidogenic pathway induced by BACE1).

	BACE1 may also be involved in other functions in the brain like the regulation of neuronal function, axonal growth, neuroprotection or synapse formation. It could ever have a role in the immunity system as several of its substrates are molecules of the immune system (like IL-1R2). These cross functions need to be investigated before any inhibitor is ~~brought~~ to the market.		BACE1 may also be involved in other functions in the brain like the regulation of neuronal function, axonal growth, neuroprotection or synapse formation. It could ever have a role in the immunity system as several of its substrates are molecules of the immune system (like IL-1R2). These cross functions need to be investigated before any inhibitor is put to the market.