1e7g: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_1e7g| PDB=1e7g | SCENE= }} | {{STRUCTURE_1e7g| PDB=1e7g | SCENE= }} | ||
=== | ===Human serum albumin complexed with tetradecanoic acid (myristic acid)=== | ||
{{ABSTRACT_PUBMED_11061971}} | {{ABSTRACT_PUBMED_11061971}} | ||
==Disease== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref><ref>PMID:7852505</ref><ref>PMID:9329347</ref><ref>PMID:9589637</ref> | [[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref> | ||
==Function== | ==Function== | ||
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref> | [[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[1e7g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[1e7g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E7G OCA]. | ||
==See Also== | ==See Also== | ||
| Line 17: | Line 17: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:011061971</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:011061971</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Bhattacharya, A A.]] | [[Category: Bhattacharya, A A.]] | ||
[[Category: Curry, S.]] | [[Category: Curry, S.]] | ||
| Line 24: | Line 24: | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
[[Category: Plasma protein]] | [[Category: Plasma protein]] | ||
[[Category: Transport protein]] | |||