Sandbox Reserved 818: Difference between revisions
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==Toxic effects of pertussis toxin== | ==Toxic effects of pertussis toxin== | ||
Pertussis toxin (PTX) is especially toxic because of its '''ADP-ribosylation activity''' on ''trimeric G proteins'' but only the '''Gα subunits''' in the G<sub>i/0</sub> family are substrates for the toxin. <br /> | |||
The ADP-ribosylation of this subunit leads to the loss of inhibition of adenylate cyclase activity, which drive to an increase of cAMP in target cells. <br /> | |||
cAMP is primary in many biological processes that's why its accumulation leads to the disruption of cellular metabolism and pathological events, according to infected cells. <br /> | |||
Thus biological activities of PTX are especially ''histamine sensitization'', ''islet activation'' and ''lymphocytosis''. | |||
==See Also== | ==See Also== | ||