Sandbox Reserved 825: Difference between revisions
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<Structure load='2npu' size='250' frame='true' align=' | <Structure load='2npu' size='250' frame='true' align='left' caption='Cartoon model of the FRB domain of mTOR: {{Template:ColorKey_N2CRainbow}}' scene='56/568023/2npu_cartoon_rainbow/4' /> | ||
As a member of '''the phosphatidylinositol kinase-related kinases''' ([http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase-related_kinase PIKK]) the mammalian targert of rapamycin ([http://en.wikipedia.org/wiki/Mammalian_target_of_rapamycin mTOR]) | As a member of '''the phosphatidylinositol kinase-related kinases''' ([http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase-related_kinase PIKK]) the mammalian targert of rapamycin ([http://en.wikipedia.org/wiki/Mammalian_target_of_rapamycin mTOR]) | ||
is a multi domain protein which is involved in the regulation of cell growth and is an important target of survival | is a multi domain protein which is involved in the regulation of cell growth and is an important target of survival | ||
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central [http://en.wikipedia.org/wiki/Focal_adhesion_targeting_region FAT] domain (residues 1513-1910), a '''FRB domain''' (residues 2015-2114) a [http://en.wikipedia.org/?title=Serine/threonine-specific_protein_kinase serine-threonine kinase] domain | central [http://en.wikipedia.org/wiki/Focal_adhesion_targeting_region FAT] domain (residues 1513-1910), a '''FRB domain''' (residues 2015-2114) a [http://en.wikipedia.org/?title=Serine/threonine-specific_protein_kinase serine-threonine kinase] domain | ||
(residues 2181-2484) and a C-terminal FATC domain (residues 2515-2549). | (residues 2181-2484) and a C-terminal FATC domain (residues 2515-2549). | ||
[[Image:The domain structure of mTOR.jpg| | |||
[[Image:The domain structure of mTOR.jpg|center|upright=3| thumb |Fig.1 Structure of mTOR.]] | |||