Sandbox Reserved 825: Difference between revisions
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MTOR has been found to form two distinct complexes called '''mTOR complex 1''' ([http://en.wikipedia.org/wiki/MTORC1 mTORC1]) and '''mTOR complex 2''' ([http://en.wikipedia.org/wiki/MTORC2 mTORC2]).<br /> | MTOR has been found to form two distinct complexes called '''mTOR complex 1''' ([http://en.wikipedia.org/wiki/MTORC1 mTORC1]) and '''mTOR complex 2''' ([http://en.wikipedia.org/wiki/MTORC2 mTORC2]).<br /> | ||
While mTORC1 is bound and inhibited by rapamycin mTORC2 is not affected by rapamycin presence. <ref> PMID: | While mTORC1 is bound and inhibited by rapamycin mTORC2 is not affected by rapamycin presence. <ref> PMID: 20005306 </ref> | ||
Depending on the formed complex mTOR activity can provoke different cellular responses like activation of tranlsation, | Depending on the formed complex mTOR activity can provoke different cellular responses like activation of tranlsation, | ||
inhibition of autophagy (mTORC1). MTORC2 on the other hand regulates the assembly of cytoskeleton and activates the | inhibition of autophagy (mTORC1). MTORC2 on the other hand regulates the assembly of cytoskeleton and activates the | ||