Ribonucleotide reductase: Difference between revisions

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Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman

Revision as of 11:57, 14 October 2013 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary ← Older edit		Revision as of 10:43, 2 January 2014 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary Newer edit →
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	{{STRUCTURE_1xjf\| PDB=1xjf \| SIZE=400\| SCENE= \|right\|CAPTION=Class III ribonucleotide reductase dimer complex with DTP and Mg+2 ion, [[1xjf]] }}		{{STRUCTURE_1xjf\| PDB=1xjf \| SIZE=400\| SCENE= \|right\|CAPTION=Class III ribonucleotide reductase dimer complex with DTP (stick model) and Mg+2 ion (green), [[1xjf]] }}

	'''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR. Class I RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction. Class II RNR reduces ribonucleotide triphosphates using coenzyme B12. Class III RNR generate glycine radical using S-adenosyl methionine and Fe-S center. For details on human RNR2 see [[P53R2]]. For mouse RNR see [[Mouse Ribonucleotide Reductase R2]].		'''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR. Class I RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction. Class II RNR reduces ribonucleotide triphosphates using coenzyme B12. Class III RNR generate glycine radical using S-adenosyl methionine and Fe-S center. For details on human RNR2 see [[P53R2]]. For mouse RNR see [[Mouse Ribonucleotide Reductase R2]].