Sandbox Reserved 813: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Sarah Welly

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 = Introduction =
-The POU family come from the acronym of three transcription factors : '''P'''it-1, '''O'''ct-1 and '''O'''ct-2 and '''U'''nc-86.
+Oct-4 for Octamer –binding transcription factor 4, also known as POU5F1 ('''POU domain, class 5, transcription factor 1''') is a 352 amino acid protein encoded by the POU5F1 gene. It is the earliest expressed gene known, and the gene is developmentally regulated during mammalian embryogenesis. The map position of oct 4 on mouse chromosome 17 is between Q and T region in the Major histocompatibility. The Oct-4 POU transcription factor is expressed in mouse totipotent embryonic stem and germ cells.
-<Structure load='3L1P' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
+Pou ( pronounced “pow”) transcription factor ( Pou stands for '''P'''it-1, '''O'''ct, '''U'''nc 86) are DNA –binding proteins that are able to activate the transcription of genes bearing cis acting elements containing an octmer motif ATGCAAAT. Pou factors possess the capability to form homo and heterodimers that can bind to octamer motif variants.
+The POU domain is a bipartite domain present in all Pou proteins. It consists of two subdomains, called the POU-specific and the POU homeodomain, connected by a flexible linker, variable in length.
+Flexibility of the linker enables the two subdomains to contact the DNA-binding site independently of each other.
+<Structure load='3L1P' size='500' frame='true' align='right' caption='Fig1: General structure of Oct-4' scene='Insert optional scene name here' />
 = Oct-4 structure =