4j7y: Difference between revisions
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{{STRUCTURE_4j7y| PDB=4j7y | SCENE= }} | |||
===Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis=== | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[http://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. | |||
==About this Structure== | |||
[[4j7y]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7Y OCA]. | |||
[[Category: Haeggstrom, J Z.]] | |||
[[Category: Niegowski, D.]] | |||
[[Category: Rinaldo-Matthis, A.]] | |||
[[Category: Leukotriene c4 synthase]] | |||
[[Category: Lipid biosynthesis]] | |||
[[Category: Lyase]] | |||
[[Category: Product analog]] | |||
Revision as of 15:13, 1 January 2014
Human LTC4 synthase in complex with product analogs - implications for enzyme catalysisHuman LTC4 synthase in complex with product analogs - implications for enzyme catalysis
DiseaseDisease
[LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
FunctionFunction
[LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
About this StructureAbout this Structure
4j7y is a 1 chain structure. Full crystallographic information is available from OCA.